It is also effective against SARS viruses such as SARS-CoV-1, which caused the outbreak in 2003. Scientists say that this discovery could pave the way for the development of a pan-coronavirus vaccine. According to a study published in science translation medicinescientists of Scripps Research The institute injected rhesus macaques, a species of Old World monkey, with two shots of the SARS-CoV-2 spike protein – the outer part on the virus that allows it to penetrate and infect host cells – to generate antibodies.
The mRNA vaccines that are currently being administered in many countries to immunize people against COVID-19 work on the same principle.
Unlike these vaccines, however, the macaques in the study were shown to have a broad neutralizing antibody response against the virus—including variants such as Omicron.
Inspired by this difference, the institute said in a press statement, their scientists Ian. collaborated with wilsonThe laboratory at Scripps Research examined antibody structures and found that these antibodies recognize a conserved region at the edge of the site where the spike protein binds to host cells, called the angiotensin converting enzyme 2 (ACE2) receptor binding site. .
“If we can design vaccines that elicit broad responses similar to those seen in this study, these treatments could enable broader protection against viruses and forms of anxiety,” said the senior author. Rais Andrabik,
“This region has rarely been targeted by human antibodies to date and suggests additional strategies that could be used to trick our immune system into recognizing this particular region of the virus,” Wilson explained.