In a new approach, scientists at the University of California, San Francisco aim to treat Alzheimer’s disease using new technology. The approach involves focusing on microglia, a type of cell that stabilizes the brain by getting rid of damaged neurons and proteins that are often associated with dementia and other brain diseases. While changes in these cells have been linked to Alzheimer’s disease, they remain to be studied. Researchers have now used a new CRISPR technique that enables them to control these microglia cells. This, according to the team, could lead to a new approach to the treatment of Alzheimer’s disease.
In BrainNormal immune cells cannot get through the blood-brain barrier. This is where microglia cells come in handy. They act as the brain’s immune system and help flush out waste and toxins while maintaining the brain neurons working fine. when these microglia Cells When they begin to lose their way, this results in inflammation in the brain and can damage neurons and their networks.
Microglia cells can also terminate the synapses between neurons under certain conditions. This process is a normal part of brain development in childhood and adolescence. But, in adults, it can have devastating effects on the brain.
The team, led by Martin Kampman, PhD, set out to locate the genes that were responsible for specific states of microglial activity. This allowed them to turn genes on and off and put the displaced cells back in their place.
they made microglia cells parent cell Donated by human volunteers and confirmed that they act like their normal human counterparts. The team then went on to develop a new platform that combines one form of CRISPR and enables researchers to turn individual genes on and off.
With this, the team was able to zero out the genes that were responsible for the cell’s ability to survive and grow. The gene also affected how actively a cell produced inflammatory substances and the aggressiveness with which a cell pruned to sync. Finding out the type of gene allowed the researchers to successfully put them to rest and replace the diseased cell with a healthy one.